Egg donation process
The egg donation process consists of several stages:
Egg Donor selection
After going to the clinic, potential oocyte donors need to go through several stages of selection before they can help couples in need. At the very beginning, the donor leaves his application for participation, after which he is contacted by the coordinator, who carries out the primary selection (by age, presence of children, no previous operations, etc.). Then the donor is invited to the clinic for the initial examination by a reproductive specialist and the collection of medical information.
At the first visit, an ultrasound examination of the pelvic organs is performed, as well as a primary blood sample to rule out infections (HIV, hepatitis B, hepatitis C, syphilis), and the level of Antimullerian hormone in the blood and blood group and rhesus factor is determined.
Consultation of a psychologist
After receiving the results of a blood test, all donors are consulted online by a psychologist about their willingness to give their eggs to other couples.
Additional donor examinations
After approval by a psychologist, donors are re-invited to the clinic for other tests (General blood analysis, coagulogram, Prolactin, Follicle-stimulating hormone, Luteinizing hormone, Estradiol, Thyroid-stimulating hormone, Urogenital smear microscopy, Papanicolaou test (PAP test), Antibodies IgG Cytomegalovirus, Antibodies IgM Cytomegalovirus, Gonorrhea (Neisseria gonorrhoeae), urine, using the method of PLR Real-Time, Chlamydia (Chlamydia trachomatis), urine, using the method of Real-Time Time), as well as for passing genetic tests: karyotyping for Chromosomal Abnormalities, DNA diagnosis of cystic fibrosis, DNA diagnosis of spinal muscular atrophy, DNA diagnosis of Martin Bell syndrome. At the request of patients, saliva and / or blood may be donated for each donor for advanced genetic testing (more than 200 genes) at a laboratory in the United States, and a clinical geneticist may be consulted upon receipt of the results.
Inclusion of the donor in the donation program
After receiving all the survey results, we create a donor profile in the OvoPuzzle egg donor database.
Once the donor profile is selected by the patients, the program can be started. On the day of the start of stimulation, each donor signs a contract with the clinic.
Ovarian stimulation usually begins at the beginning of the donor's menstrual cycle and lasts 10-14 days. During this period, donors receive injections of hormonal drugs containing FSH, which stimulate follicle growth, and after the follicles reach 14 mm - GnRH antagonist, to prevent premature release of LH hormone and rupture of follicles.
During the period of stimulation, 3-4 ultrasounds are performed, during which the doctor measures the follicles, adjusts the dosage of FSH and monitors the condition of the donor. After the follicles reach maturity (18-24 mm in diameter)
The donor is prescribed an ovulation trigger, a GnRH agonist that causes oocytes to mature inside the follicles without increasing the risk of developing donor ovarian hyperstimulation syndrome.
35-36 hours after ovulation trigger, oocyte collection is performed by transvaginal follicle puncture. The procedure is performed under intravenous anesthesia and lasts 15-20 minutes, painless. On the same day, blood is collected to determine: NAAT test to HBV, HCV and HIV.
After that, the oocytes are cleaned and prepared by embryologists either for fertilization or for rapid freezing (vitrification). The donor is under medical supervision for several hours, after which he consults a doctor, we receive recommendations.
After that, the donor receives compensation for the time spent, signs the acts of work performed and can be released home. In the next 14 days after the oocyte collection, the donor is assisted by a physician's assistant and coordinator. In the next menstrual cycle after stimulation, a control ultrasound of the pelvic organs must be performed for all donors.
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